- PII
- S2658655X25070112-1
- DOI
- 10.7868/S2658655X25070112
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 111 / Issue number 7
- Pages
- 1185-1197
- Abstract
- A flow system model simulating the hemodynamic process in capillaries was created to study neutrophil migration. It was found that the general patterns of neutrophil behavior (aggregate formation, formation of neutrophil tethers and migration of neutrophils along intercellular contacts of endothelial cells) are reproduced both in the control (system without chemoattractants) and in the experiment (system with low-molecular chemoattractants of bacteria), however, in the case of and using as a chemoattractant, the number of aggregates and neutrophil tethers increases statistically significantly ( < 0.05). Aggregates correspond to the swarming phenomenon in the transendothelial migration system and help limit the zone of bacterial damage. And neutrophil tethers cause a stop in hemodynamic movement and can cause either a transition to migration or be precursors to the formation of elongated neutrophil-derived structures with high antibacterial potential. Thus, all the observed phenomena contribute to the implementation of the protective function in case of bacteremia.
- Keywords
- миграция нейтрофилы хемоаттрактанты эндотелиоциты кровоток “нейтрофильные привязи” агрегация
- Date of publication
- 21.12.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 22
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