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RAS PhysiologyРоссийский физиологический журнал им. И.М. Сеченова Russian Journal of Physiology

  • ISSN (Print) 0869-8139
  • ISSN (Online) 2658-655X

The effect of chronic stress and TAAR1 knockout on behavior characteristics of mice in tests assessing depressive-like behavior

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PII
S2658655X25070122-1
DOI
10.7868/S2658655X25070122
Publication type
Article
Status
Published
Authors
E. P. Vinogradova
  • Affiliation: Saint Petersburg State University
A.Y. Aleksandrov
  • Affiliation: Saint Petersburg State University
D.V. Belyakov
  • Affiliation: Saint Petersburg State University
E.S. Dmitrieva
  • Affiliation: Saint Petersburg State University
L.N. Stankevich
  • Affiliation: Saint Petersburg State University
A.A. Aleksandrov
  • Affiliation: Saint Petersburg State University
Volume/ Edition
Volume 111 / Issue number 7
Pages
1198-1210
Abstract
The aim of the study was to study the functional role of the TAAR1 receptor in the formation of the behavioral component of the stress response. The behavior of TAAR1–KO knockout mice and wild type (WT) mice was studied in tests reflecting a depressive-like state before and after the end of chronic stress (predator stress model), as well as delayed behavioral changes after 6 weeks. In the "hanging by the tail" test and the forced swimming Porsolt test, there were no differences between the TAAR1–KO and WT groups in terms of depressive-like behavior both during normal and after chronic stress exposure. However, TAAR1–KO mice, when placed in a stressful situation at the beginning of testing, demonstrate motor hyperactivity, which leads to a sharp increase in the latency periods of the first immobilization in both tests. Knockout of the TAAR1 receptor does not affect the signs of depressive-like behavior; however, it leads to a characteristic increase in the level of motor activity. TAAR1–KO mice demonstrated a more pronounced reaction to chronic stress exposure; weight gain after the end of the stressor occurred significantly slower than in WT mice, so that for the last 5 weeks the body weight of TAAR1–KO animals was significantly less than that of wild-type mice. It was found that 6 weeks after the end of stress exposure, the indicators of depressive-like state in TAAR1–KO and WT mice continue to increase.
Keywords
нокауты TAAR1–KO тест подвешивания за хвост тест Порсолта хронический стресс “запаха хищника” депрессивноподобное состояние стресс-индуцированная гипертермия
Date of publication
21.12.2025
Year of publication
2025
Number of purchasers
0
Views
38

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