RAS PhysiologyРоссийский физиологический журнал им. И.М. Сеченова Russian Journal of Physiology

  • ISSN (Print) 0869-8139
  • ISSN (Online) 2658-655X

Possibilities and Limitations of Using the Olfactory Bulb Removal Model in Rodents

PII
S2658655XS0869813925050013-1
DOI
10.7868/S2658655X25050013
Publication type
Review
Status
Published
Authors
Volume/ Edition
Volume 111 / Issue number 5
Pages
639-658
Abstract
Here, we review current data that provide a basis for using the olfactory bulbectomy model as a model of mental disorders in humans. Based on extensive literature and our own data, we have shown the possibilities of using the olfactory bulbectomy model in rodents as a model of depression and Alzheimer's disease, taking into account the correspondence of the observed changes with modern criteria of validity. The removal of olfactory bulbs causes a complex of molecular, structural, and behavioral changes in animals, which cannot serve as an ideal model for certain disease. The review discusses the limitations of using this model and interpreting the results. Nevertheless, this model can be a useful tool for both basic and applied studies of brain pathologies, taking into account these limitations.
Keywords
ольфакторная бульбэктомия депрессия болезнь Альцгеймера крыса мышь животная модель
Date of publication
15.05.2025
Year of publication
2025
Number of purchasers
0
Views
53

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